Kerman Coronary Artery Diseases Riskfactor Study-KERCADRS 

The study was conducted on residents of Kerman city aged 15-75 years. The sampling unit consisted of households residing in Kerman for at least one year. Using a single-stage random cluster sampling method and postal codes as the sampling frame (250 codes), individuals were enrolled. They were invited to visit the research clinic in the morning after 10-12 hours of fasting. All participants signed a written consent form and were examined for 10 coronary artery disease risk factors including hypertension, diabetes, obesity, physical inactivity, mental health, smoking and addiction, oral and dental hygiene, nutrition, sleep quality, and laboratory tests (FBS, HbA1c, TG, Chol, HDL, LDL). Demographic data such as height, weight, waist circumference, and education level were also recorded. A portion of the serum was stored in the center's biobank at -75°C, and whole blood samples on DNA cards or extracted DNA were also stored.The second phase was repeated five years later (2014-2018), with 2,800 out of the 5,900 phase one participants re-enrolled. New individuals were added to reach a sample size of 10,000 using the same method as phase 1, expanding postal codes to 420. The age range in phase two was 15-80 years. Participants were asked to bring their medications on the day of the visit.The third phase began in 2019, five years after phase two, by recalling phase 2 participants.The sample size of 10,000 and it is now completed.Outcomes investigated include the point prevalence and 5- or 10-year incidence of the 10 risk factors, incidence of heart attack and stroke, causes of hospitalization, crude mortality rate, and cause-specific mortality related to cardiovascular diseases.

Phase 1 (September 2009 - September 2011):

• Age range: 15-75 years
• Sample size: 6,000 individuals

Phase 2 (September 2014 - September 2018):

• Age range: 15-80 years
• Sample size: 10,000 individuals

Phase 3 (November 2019 – July 2024):

• Age range: 15-85 years
• sample size: 10,000 individuals

Sampling Method:

• Phase 1: Random sampling from households in 250 postal codes in the city
• Phases 2 and 3: Random sampling from households in 420 postal codes

10 Risk Factors Investigated:

1. Diabetes
2. Hypertension
3. Obesity and overweight
4. Physical activity level
5. Hyperlipidemia
6. Addiction, smoking, and hookah use
7. Nutrition
8. Anxiety and depression
9. Oral and dental hygiene
10. Sleep quality

Follow up:

To follow up on the participants in the Cohort , all 10,000 of them are contacted by telephone once a year by trained social workers and follow-up questionnaires are completed for events over the past year.

Published Articles Based on Cohort Data:

• Phase 1: 43 articles
• Phase 2: 41 articles
• Phase 3:  2 articles
• Total: 86 articles

Serum and Blood or DNA Samples Stored in the Center's Biobank:

• Phase 1: 6,000 samples
• Phase 2: 10,000 samples
• Phase 3 :10000 samples
• Total: 26000 serum and 26000 DNA(or blood)